New PDF release: 11th Annual meeting of the EBMT: European Cooperative Group

By Th. Büchner (auth.), W. Hinterberger, A. J. Barrett, K. Lechner, E. Deutsch (eds.)

ISBN-10: 3662393999

ISBN-13: 9783662393994

ISBN-10: 3662404575

ISBN-13: 9783662404577

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Additional resources for 11th Annual meeting of the EBMT: European Cooperative Group for Bone Marrow Transplantation

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Baumga rtner e t a l, Me d Pediatr On col 12 : 104- 111' 198 4 2 . Baumga r t ner et a l, Exp Hema t ol 11 (Suppl 14) : 6 , 1 983 3 . For s t er et al , Can c er Res 42 : 1 927- 19 34, 1982 Exp. Hematol. (suppl. 17) 13:28-29 (1985) © International Society for Experimental Hematology In vitro Marrow Purging with Anti-DR Monoclonal Antibodies and Complement in High Dose Risk ALL Preclinical Studies and Preliminary Clinical Experience Dominique Maraninchi 5 , Claude Mawas \ Brynhild Maseret 5 , Gerard Sebahoun 5 , Jean-Albert Gastaut 5 , Nicole Tubiana 5, Henri Perrimond 2 , Joelle Scavennec 3 , Giseie Novakovitch 4 , and Yves Carcassonne 5 1 2 3 4 5 Unite I 19 INSERM, Marseille Service de Pediatrie A, CHU Timone, Marseille Societe Immunotech, Marseille Regional Blood Bank, Marseille Marrow Transplant Unit, Clinique des Maladies du Sang, Institut Paoli-Calmettes, Marseille, France - Human DR antigens are histocompatibility antigens close to the la murine antigens.

Martinengo \ A. Congiu \ S. Nati \ D. Giordano \ and A. M. Marmont 1 1 2 3 Division of Hematology, Genova, Italy National Cancer Institute, Milan, Italy Division ofHematology, Bozen, Italy The optimal management of pat i ents who deve l op progressive or recurrent disease after primary chemotherapy remai ns to be estab l i shed. New salvageregimens have been shown tobe able to control the disease in many relapsed patients. There is, however, a sizable group of truly malignant patients who either fail to achieve a remission or relapse after few months and respond poorly even to powerful salvage regimens such as CEP (CCNU+Etoposide+prednimustine).

In view o f t he h e t e r ogenei t y o f ob served loarterm s equelae, a s pecifi c t oxic effec t o f t he purging pro cedure appears to be unlikel y. 1 2 3 4 5 s 1 a Heigh t after 9 pati en t s male 9 m" ~ c ~ ~ e v ABMT w i th B· NHL 40 30 20 Weight 01 2 3 4 5 6 7 8 9 10 Age , aft er 11 12 y e ars c ABMT 14 15 16 17 18 10 ° Fi g . 1 . Gr owth a fter ABMT . Th e shaded a rea indicates t he nor mal range (3rd to 97th percenti l e) . References : l . Baumga rtner e t a l, Me d Pediatr On col 12 : 104- 111' 198 4 2 .

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11th Annual meeting of the EBMT: European Cooperative Group for Bone Marrow Transplantation by Th. Büchner (auth.), W. Hinterberger, A. J. Barrett, K. Lechner, E. Deutsch (eds.)


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